In 2019,Synlett included an article by Asquith, Christopher R. M.; Konstantinova, Lidia S.; Tizzard, Graham J.; Laitinen, Tuomo; Coles, Simon J.; Rakitin, Oleg A.; Hilton, Stephen T.. HPLC of Formula: 17201-43-3. The article was titled 《Exploration and Development of a C-H-Activated Route to Access the [1,2]Dithiolo[4,3-b]indole-3(4H)-thione Core and Related Derivatives》. The information in the text is summarized as follows:
N-Substituted 2-methylindoles I [R = H, F; R1 = Me, Et, i-Pr, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2, 3,4-(MeO)2C6H3, 3-F-4-MeOC6H3] underwent chemoselective oxidative cyclocondensation reactions with the DABCO complex of S2Cl2 (generated in situ from S2Cl2 and DABCO) in CHCl3 followed by Et3N to yield dithioloindolethiones II [R = H, F; R1 = Me, Et, i-Pr, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2, 3,4-(MeO)2C6H3, 3-F-4-MeOC6H3]. I (R = H, F; R1 = Me, Et, i-Pr, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2) were prepared by N-alkylation of 2-methylindoles with alkyl bromides using either KOH in DMF or NaH and NaI in THF. The structures of I [R = H, F; R1 = Me, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2, 3,4-(MeO)2C6H3, 3-F-4-MeOC6H3] were determined by X-ray crystallog. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3HPLC of Formula: 17201-43-3)
4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.HPLC of Formula: 17201-43-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts