《C-Alkylation of Various Carbonucleophiles with Secondary Alcohols under CoIII-Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Chakraborty, Priyanka; Garg, Nidhi; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker. SDS of cas: 31938-07-5 The article mentions the following:
Oxindoles have been successfully α-alkylated under Cp*CoIII catalysis by a vast array of secondary alcs., including cyclic, acyclic, sym., and unsym., to produce C-alkylated oxindoles. This protocol was also extended to the α-alkylation of N,N-di-Me barbituric acid and benzyl cyanides. The kinetic profile and other preliminary mechanistic investigations suggest a first-order reaction rate in oxindoles and catalysts. A plausible catalytic cycle is proposed on the basis of the kinetic profile, of other preliminary mechanistic investigations, and of previous mechanistic studies on similar transformations, whereas d. functional theory calculations provide insight into the nature of the active species. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.SDS of cas: 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts