Recommanded Product: 17201-43-3In 2019 ,《Quinoline-1,2,3-triazole Hybrids: Design and Synthesis through Click Reaction, Evaluation of Anti-Tubercular Activity, Molecular Docking and In Silico ADME Studies》 appeared in ChemistrySelect. The author of the article were Reddyrajula, Rajkumar; Dalimba, Udayakumar. The article conveys some information:
A new series of quinoline-1,2,3-triazole derivatives I (R = benzyl, phenacyl, 4-methoxy phenacyl, etc.), II were designed based on the mol. hybridization concept and the mols. were synthesized by employing a click chem. approach. The pharmacophoric units (quinoline and 1,2,3-triazole) are linked through either an ether or an amide functionality; such a simple structural modification of the linker group significantly enhanced the anti-tubercular activity of the mols. and all the amide derivatives showed better inhibition activity as compared to their ether analogs. However, these compounds did not inhibit significantly the growth of tested bacterial strains: the activity profile is similar to that observed for standard anti-TB drugs indicating the specificity of these compounds towards the M.tuberculosis strain. The mol. docking studies of the active compounds with two target enzymes (Inh A and CYP121) of M.tuberculosis revealed the strong binding interactions, mainly through hydrogen bonding, between the mols. and the target receptors. Furthermore, prediction of in silico-ADME (A: absorption, D: distribution, M: metabolism and E: excretion) parameters indicated that these compounds have an excellent oral bioavailability. The results suggest that these quinoline-1,2,3-triazole hybrids are a promising class of mol. entities for the development of new anti-tubercular leads.4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 17201-43-3) was used in this study.
4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Recommanded Product: 17201-43-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts