《Well-Defined Palladium N-Heterocyclic Carbene Complexes: Direct C-H Bond Arylation of Heteroarenes》 was written by Kumar, Anuj; Kumar, Manoj; Verma, Akhilesh K.. Application In Synthesis of 4-Bromobenzonitrile And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:
A series of palladium N-heterocyclic carbene (NHC) complexes of type trans-{(NHC)PdCl2L} (L = C5H5N, 3-ClC5H4N, and PPh3) have been developed as efficient precatalysts for direct C-H bond arylation of various heteroarenes. In particular, an in situ generated new NHC ligand derived from {1,3-bis(2,6-diethylphenyl)acenaphtho[1,2-d]imidazolium} chloride is used for the stabilization of the palladium metal center. Among the screened palladium precatalysts, the most active PEPPSI themed complex was successfully employed toward direct C-H bond arylation of various heteroarenes and aryl bromides. A range of functional groups on aryl bromides as well as on heteroarenes sustained throughout the standard reaction conditions for easy access of various arylated heterocyclic compounds Significantly, the utility of the protocol was demonstrated by the effective synthesis of a precursor of raloxifene, a selective estrogen receptor modulator.4-Bromobenzonitrile(cas: 623-00-7Application In Synthesis of 4-Bromobenzonitrile) was used in this study.
4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Application In Synthesis of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts