《Nucleophilic Acylation with Aromatic Aldehydes to 2 Bromoacetonitrile: An Umpolung Strategy for the Synthesis of Active Methylene Compounds》 was published in Current Organic Synthesis in 2020. These research results belong to Singh, Shailesh; Tiwari, Jyoti; Jaiswal, Deepali; Sharma, Amit Kumar; Singh, Jaya; Singh, Vandana; Singh, Jagdamba. Related Products of 614-16-4 The article mentions the following:
A novel one-pot N-heterocyclic carbene (NHC)-catalyzed acylation of 2-bromoacetonitrile with aromatic aldehydes ArCHO (Ar = Ph, 2-chlorophenyl, furan-2-yl, etc.) is reported. The protocol involves carbonyl umpolung reactivity of aldehydes in which the carbonyl carbon attacks nucleophilically (as d1 nucleophile) on the electrophilic terminal of 2-bromoacetonitrile to afford 3-aryl-3-oxopropanenitriles ArC(O)CH2CN. The salient features of this procedure are short reaction time, operational simplicity, ambient temperature, no byproduct formation and high yields. After reading the article, we found that the author used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Related Products of 614-16-4)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Related Products of 614-16-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts