Product Details of 614-16-4In 2019 ,《Convenient synthesis of linear 2H,6H-pyrano[3,2-g] chromenes from natural occurring compound; visnagin》 appeared in Synthetic Communications. The author of the article were Abdel-Aziem, Anhar; El-Sawy, Eslam R.; Kirsch, Gilbert. The article conveys some information:
A simple and convenient route for the synthesis of linear 2-imino-2H,6H-pyrano[3,2-g] chromene-6-ones/2H,6H-pyrano[3,2-g]chromene-2,6-diones I (X = NH, O; R = 2-oxo-2-phenylethyl, 2-(1-benzofuran-2-yl)-2-oxoethyl, 1,3-benzothiazol-2-ylmethyl, etc.) has been described starting from natural occurring furochromone; visnagin. Ring opening of visnagin yielded 6-formyl-7-hydroxy-5-methoxy-2-methylchromone, which underwent reaction with different acetonitrile derivatives RCH2CN furnished 2-imino-2H,6H-pyrano[3,2-g]chromene-6-ones I (X = NH). Acid hydrolysis led to the formation of 2H,6H-structures pyrano[3,2-g]chromene-2,6-diones I (X = O). The entire target compounds were selected for in vitro anticancer activity against 60 human cancer cell lines at a single dose (10-5 M) by the National Cancer Institute (NCI, Bethesda, USA). In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Product Details of 614-16-4)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Product Details of 614-16-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts