Application of 2042-37-7In 2021 ,《Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles》 appeared in Chemistry – An Asian Journal. The author of the article were Kim, Hyeongsu; Xuan, Zi; Hyun Kim, Ju. The article conveys some information:
An efficient tandem route to obtain tetrasubstituted NH pyrroles I (R = Me, Et, Bn; Ar = Ph, 2-naphthyl, pyridin-3-yl, etc.) in a one-pot manner has been developed, staring from simple nitriles ArCN, Et bromoacetates BrCH2CO2R, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles I in yields up to 91%. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7Application of 2042-37-7)
2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Application of 2042-37-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts