Gonzalez-Fernandez, Rebeca; Crochet, Pascale; Cadierno, Victorio published the artcile< Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations>, Category: nitriles-buliding-blocks, the main research area is ketonitrile preparation ruthenium catalyst tandem hydration transfer hydrogenation; hydroxyamide preparation.
A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides was reported. The process, that proceeded in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate involved the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles featuring diverse substitution patterns, the scope and limitations of the processed was established.
Journal of Organometallic Chemistry published new progress about Amides, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts