Synthetic Route of 1572-52-7, These common heterocyclic compound, 1572-52-7, name is 2-Methylenepentanedinitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
130 g (1 M) of N-(2-hydroxyethyl)imidazolidin-2-one and 2 g of potassium hydroxide pellets are charged to a 500 cm3 reactor equipped with a mechanical stirrer, a jacket forheating, a dropping funnel and a system for rendering inertwith nitrogen. The product is brought to 80 C. and then 116g (1.1 M) of methyleneglutaronitrile are run in slowly. At theend of the reaction, when there is virtually no more methyleneglutaronitrile, the catalyst is neutralized with an acid.The expected dinitrile is obtained with a yield of 95%. Theproduct can be used as is or purified by distillation in orderto separate it from the excess methyleneglutaronitrile.
Statistics shows that 2-Methylenepentanedinitrile is playing an increasingly important role. we look forward to future research findings about 1572-52-7.
Reference:
Patent; Arkema France; Gillet, Jean-Philippe; Disson, Jean-Pierre; Van Hemelryck, Bruno; (13 pag.)US10047195; (2018); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts