In 2005,Baxendale, Ian R.; Ley, Steven V. published 《Formation of 4-Aminopyrimidines via the Trimerization of Nitriles Using Focused Microwave Heating》.Journal of Combinatorial Chemistry published the findings.COA of Formula: C8H6BrN The information in the text is summarized as follows:
A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantities of the corresponding 4-amino pyrimidine derivatives have been prepared in high yields and purity following a simple and scaleable protocol. In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5COA of Formula: C8H6BrN) was used in this study.
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.COA of Formula: C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts