Liu, Hui; Yan, Yingkun; Zhang, Jiayan; Liu, Min; Cheng, Shaobing; Wang, Zhouyu; Zhang, Xiaomei published the artcile< Enantioselective dearomative [3+2] annulation of 5-amino-isoxazoles with quinone monoimines>, Synthetic Route of 21667-62-9, the main research area is aminoisoxazole quinone monoimine chiral phosphoric acid catalyst dearomative cycloaddition; benzofuroisoxazole diamine preparation enantioselective; quinone monimine aminoisoxazole phosphoric acid tandem dearomative cycloaddition cyclization; epoxyazenometheno dihydrobenzofuropyrrolyl benzenesulfonamide preparation enantioselective.
The first enantioselective dearomative [3+2] annulation of 5-aminoisoxazoles with quinone monoimines was realized using a chiral phosphoric acid as catalyst. Various novel (bridged) isoxazoline fused dihydrobenzofurans bearing two continuous quaternary stereocenters were achieved in moderate to good yields (up to 94%) with moderate to good enantioselectivities (up to 98% ee). The absolute configurations of two products were assigned by X-ray crystal structural analyses and a plausible reaction mechanism was proposed.
Chemical Communications (Cambridge, United Kingdom) published new progress about [3+2] Cycloaddition reaction catalysts (dearomative, stereoselective). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Synthetic Route of 21667-62-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts