El-serwy, Walaa s.; El-serwy, Weam s.; Mohamed, Neama a.; Kassem, Emad m. m.; Mostafa, Rasha e.; Mohamed, Hanaa s. published their research in Russian Journal of Bioorganic Chemistry in 2021. The article was titled 《Synthesis, Biological Evaluation, Molecular Docking, ADME Predictions and QSAR Studies of Novel 1,2-Diazet and Pyrrole Derivatives as Anti-Inflammatory Agents》.Category: nitriles-buliding-blocks The article contains the following contents:
Here we synthesized novel 1, 2-diazet and pyrrole derivatives and screened for their anti-inflammatory activity. In vivo anti-inflammatory evaluation results revealed that compounds (XVI), (XIV) and (XI) exhibited the highest anti-inflammatory potencies all over the 4 h, while compounds (VII), (V) and (XV) exhibited the lowest potencies when compared to indomethacin group. Mol. docking study was used to predict the binding mode towards c-Jun N-Terminal Kinase. In addition, ADME (absorption, distribution, metabolism, and excretion) prediction and QSAR (quant. structure-activity relationship) study of compounds was carried out resp. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts