Dahatonde, Dipak J.; Ghosh, Aritra; Batra, Sanjay published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Metal-Free Synthesis of Alkenylazaarenes and 2-Aminoquinolines through Base-Mediated Aerobic Oxidative Dehydrogenation of Benzyl Alcohols》.Electric Literature of C8H6BrN The article contains the following contents:
A metal-free, base-mediated, and atom-efficient oxidative dehydrogenative coupling of substituted phenylmethanols (benzyl alcs.) with Me azaarenes or phenylacetonitriles to afford substituted alkenylazaarenes or 2-aminoquinolines, resp. was described. CsOH. H2O was discovered to be the base of choice for obtaining optimal yields of the title compounds, although the reaction proceeded with KOH as well. The protocol that worked efficiently in the presence of air was amenable over broad range of substrates. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Electric Literature of C8H6BrN)
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Electric Literature of C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts