In 2022,Liu, Wei; Zhang, Le; Liu, Ye; Fan, Shi-Lu; Dai, Jian-Jun; Tao, Wei; Zhu, Hui-Xia; Xiao, Hua published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Chemoselective tandem SN2’/SN2”/inter- or intramolecular Diels-Alder reaction of γ-vinyl MBH carbonates with phenols and o-hydroxychalcones》.Recommanded Product: 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:
An unprecedented consecutive SN2’/SN2” addition of phenol to γ-vinyl MBH carbonate formed a reactive diene intermediate, followed by a dimerization/elimination process to give functionalized exocyclohexenes I [R = (CF3)2CH, Ph, 2-MeC6H4, etc.] with excellent chemoselectivity. When using o-hydroxychalcones as pronucleophiles, an SN2’/SN2”/intramol. Diels-Alder reaction sequence occurred, selectively producing a series of pharmaceutically intriguing tricyclic chromane derivatives II [R1 = H, 4-Me, 2-Cl, etc.; R2 = OEt, Ph, 1-naphthyl, etc.] with good diastereoselectivity. The good nucleophilicity and fair nucleofugicity exhibited by phenoxy anion played a pivotal role in the SN2” addition step. In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Recommanded Product: 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts