Sun, Huan; Jiang, Yue; Lu, Ming-Kun; Li, Yun-Yun; Li, Li; Liu, Ji-Kai published the artcile< Iron-Catalyzed Tandem Radical Addition/Cyclization: Highly Efficient Access to Methylated Quinoline-2,4-diones>, Application In Synthesis of 38487-85-3, the main research area is methyl quinoline dione preparation; cyanoaryl acrylamide dimethyl sulfoxide photochem methylation iron catalyst.
A visible-light-induced and iron-catalyzed oxidative radical addition/cyclization cascade reaction of N-(o-cyanoaryl)acrylamides I [R1 = 4-Cl, 5-CF3, 3-Br, etc.; R2 = Me, Bn; R3 = Me, [(2,2-dimethylpropanoyl)oxy]methyl, Bn, Ph, (acetyloxy)methyl, (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl] with DMSO has been developed. The method exhibits a wide substrate scope and an excellent functional-group tolerance, thus providing an efficient and convenient access to a variety of methylated quinoline-2,4-diones II (R4 = 6-Cl, 6-CF3, 5-Br, etc.).
Synlett published new progress about Acrylamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Application In Synthesis of 38487-85-3.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts