Synthetic Route of 77668-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 77668-42-9 name is 2,3-Dichlorobenzoyl cyanide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
6. Synthesis of lamotrigine via the tetrafluoroborate salt as a one-pot reactionThe condensation step was performed as described in example 5, with the exception that the isolation of the tetrafluoroborate intermediate was omitted. After the condensation step the solvents were removed on a rotary evaporator, then an equal volume of acetonitrile was added and the subsequent cyclization step was performed as described in example 2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichlorobenzoyl cyanide, and friends who are interested can also refer to it.
Reference:
Patent; LONZA AG; WO2008/19798; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts