Synthetic Route of 92616-49-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92616-49-4, name is 4-Bromo-1-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 4-bromo-1-naphthonitrile (230 mg, 0.991 mmol), bis(pinacolato)diboron (277 mg,1.090 mmol), potassium acetate (292 mg, 2.97 mmol) in DMSO (2 ml) was degassed and treatedwith PdC12(dppf) (21.75 mg, 0.030 mmol). The mixture was then capped and heated to 80 Covernight. The reaction mixture was then washed with water and exctracted with ethyl acetate. Theorganics were collected, dried, filtered, and concentrated. The mixture was purified by silica gel chromatography (24 G, 0-50% EtOAc-hexanes) to provide 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1-naphthonitrile as a white solid (118 mg, 43%). 1H NMR (400 MHz, Chloroform-d) 8.86-8.80 (m, 1H), 8.30-8.24 (m, 1H), 8.08 (d, J= 7.1 Hz, 1H), 7.89 (d, J 7.1Hz, 1H), 7.71 – 7.62 (m, 2H), 1.44 (s, 12H).
The synthetic route of 4-Bromo-1-naphthonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; LEE, Arthur; MCKEW, John, C.; PATEL, Paresma, R.; YU, Paul, B.; MOHEDAS, Agustin, H.; SANDERSON, Philip, E.; ZHENG, Wei; HUANG, Xiuli; UNIVERSITY OF HOUSTON SYSTEM; CUNY, Gregory, D.; (304 pag.)WO2016/11019; (2016); A1;,
Nitrile – Wikipedia,
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