In 2014,Mentese, Emre; Bektas, Hakan; Uelker, Serdar; Bekircan, Olcay; Kahveci, Bahittin published 《Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity》.Journal of Enzyme Inhibition and Medicinal Chemistry published the findings.Product Details of 31938-07-5 The information in the text is summarized as follows:
A practical protocol was used for the synthesis of benzimidazoles. The reaction of Et phenylacetimidate hydrochlorides with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. The corresponding ester and hydrazide derivatives were synthesized subsequently under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and benzimidazoles I (R = H, R1 = Br; R = Br, R1 = H) and II (R = H, CH2CO2Me) showed lipase inhibition at various concentrations2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Product Details of 31938-07-5) was used in this study.
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Product Details of 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts