Mokhtar, Mohamed; Alghamdi, Khadijah S.; Ahmed, Nesreen S.; Bakhotmah, Dina; Saleh, Tamer S. published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021. The article was titled 《Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases》.Name: 3-Oxo-3-phenylpropanenitrile The article contains the following contents:
A new set of 4,6,7,8-tetrahydroquinolin-5(1H)-ones were designed as cytotoxic agents against breast cancer cell line (MCF-7) and synthesized under ultrasonic irradiation using chitosan decorated copper nanoparticles (CS/CuNPs) catalyst. The new compounds , , , and exhibited the most potent cytotoxic activity of IC50 values (0.002 – 0.004μM) comparing to Staurosporine of IC50; 0.005μM. The latter derivatives exhibited a promising safety profile against the normal human WI38 cells of IC50 range 0.0149 – 0.048μM. Furthermore, the most promising cytotoxic compounds , were evaluated as multi-targeting agents against the RTK protein kinases; EGFR, HER-2, PDGFR-β, and VEGFR-2. Compound 4j showed promising inhibitory activity against HER-2 and PDGFR-β of IC50 values 0.17 x 10-3, 0.07 x 10-3μM in comparison with the reference drug sorafenib of IC50; 0.28 x 10-3, 0.13 x 10-3μM, resp. In addition, induced apoptotic effect and cell cycle arrest at G2/M phase preventing the mitotic cycle in MCF-7 cells. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Name: 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts