《NHC-catalyzed silylative dehydration of primary amides to nitriles at room temperature》 was written by Hota, Pradip Kumar; Maji, Subir; Ahmed, Jasimuddin; Rajendran, N. M.; Mandal, Swadhin K.. Product Details of 2042-37-7 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:
In the presence of the abnormal imidazolylidene carbene I, primary amides underwent chemoselective dehydrogenative dehydration reactions with phenylsilane to yield nitriles; the method bypasses the energetically demanding 1,2-siloxane elimination step usually required for metal/silane catalyzed reactions. The mechanism of the was dehydrogenative dehydration studied using DFT calculations of the transition state structures and their free energies and enthalpies on the dehydration pathway; a silane adduct of I was characterized by NMR and evidence for the formation of H2 and of a disiloxane byproduct provided. In the experiment, the researchers used many compounds, for example, 2-Bromobenzonitrile(cas: 2042-37-7Product Details of 2042-37-7)
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Product Details of 2042-37-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts