In 2022,Wu, Yong; Guo, Qing-Hui; Qiu, Yunyan; Weber, Jacob A.; Young, Ryan M.; Bancroft, Laura; Jiao, Yang; Chen, Hongliang; Song, Bo; Liu, Wenqi; Feng, Yuanning; Zhao, Xingang; Li, Xuesong; Zhang, Long; Chen, Xiao-Yang; Li, Hao; Wasielewski, Michael R.; Stoddart, J. Fraser published an article in Proceedings of the National Academy of Sciences of the United States of America. The title of the article was 《Syntheses of three-dimensional catenanes under kinetic control》.Synthetic Route of C8H6BrN The author mentioned the following in the article:
Although catenanes comprising two ring-shaped components can be made in large quantities by templation, the preparation of three-dimensional (3D) catenanes with cage-shaped components is still in its infancy. Here, the design and syntheses of two 3D catenanes by a sequence of SN2 reactions in one pot is reported. The resulting triply mech. interlocked mols. were fully characterized in both the solution and solid states. Mechanistic studies have revealed that a suit[3]ane, which contains a threefold sym. cage component as the suit and a tribromide component as the body, is formed at elevated temperatures This suit[3]ane was identified as the key reactive intermediate for the selective formation of the two 3D catenanes which do not represent thermodn. min. This particular synthetic strategy might be used in the future to guide the rational design and production of mech. interlocked mols. under kinetic control. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Synthetic Route of C8H6BrN)
4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Synthetic Route of C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts