Yan, Yingkun; Li, Min; Liu, Min; Huang, Min; Cao, Lianyi; Li, Wenzhe; Zhang, Xiaomei published the artcile< Sc(OTf)3-Catalyzed Dearomative [3+2] Annulation of 5-Aminoisoxazoles with Quinone Imine Ketals or Quinone Monoacetals>, HPLC of Formula: 21667-62-9, the main research area is indoline fused isoxazoline preparation diastereoselective; dihydrobenzofuran fused isoxazoline preparation diastereoselective; aminoisoxazole quinone imine ketal cyclization scandium triflate catalyst; quinone monoacetal aminoisoxazole cyclization scandium triflate catalyst.
Sc(OTf)3-catalyzed dearomative [3+2] annulations of 5-aminoisoxazoles I (R1 = Me, 4-chlorophenyl, thiophen-2-yl, etc.; R2 = Me, Et, 4-bromophenyl, 3-chlorophenyl; R3 = Me, Et) with quinone imine ketals (QIKs) II (R4 = NTs; R5 = H) and quinone monoacetals (QMAs) II (R4 = O; R5 = H, Me, Cl, Br) were reported. A variety of indoline- and 2,3-dihydrobenzofuran-fused isoxazolines III, IV were afforded in moderate to good yields with excellent diastereoselectivities (all cases >20 : 1 dr). This method featured mild reaction conditions, wide substrate scope, and gram-scale synthesis.
European Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, HPLC of Formula: 21667-62-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts