Balwe, Sandip Gangadhar; Jeong, Yeon Tae published the artcile< New efficient synthesis of benzofuro[2,3-b]pyrroles utilizing a reactive nitrilium trapping approach by an acid-promoted cascade addition/cyclization sequence>, Electric Literature of 21667-62-9, the main research area is tricyclic benzofuropyrrole preparation; hydroxybenzaldehyde aroylacetonitrile isocyanide cascade addition heterocyclization toluenesulfonic acid catalyst.
The first p-TSA.H2O-catalyzed highly efficient one-pot cascade reaction for the synthesis of novel fused tricyclic benzofuro[2,3-b]pyrroles I (R = t-Bu, Cy; R1 = H, 3-Cl, 3-Me, 4-F; R2 = H, 7-MeO, 7-EtO, 5-Br, 5-Cl) has been discovered. The reaction sequence involves a Knoevenagel condensation of 2-hydroxybenzaldehydes R3-2-HO-C6H3CHO (R3 = H, 3-MeO, 3-EtO, 5-Cl, 5-Br) with aroylacetonitriles R1C6H4C(O)CH2CN followed by subsequent nucleophilic addition of the divalent isocyano carbon to generate highly reactive nitrilium carbon, which could be readily trapped by an adjacent phenolic group of 2-hydroxybenzaldehydes to access diverse benzofuro[2,3-b]pyrroles I in one pot. This approach features a robust one-step protocol with broad substrate scope, good functional group tolerance, and promising application prospects in the synthesis of complex tricyclic N-heterocycles I.
New Journal of Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (aroyl). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Electric Literature of 21667-62-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts