Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. SDS of cas: 105-34-0.
Gaber, Ahmed;Alsanie, Walaa F.;Alhomrani, Majid;Alamri, Abdulhakeem S.;El-Deen, Ibrahim M.;Refat, Moamen S. research published 《 Synthesis and characterization of some new coumarin derivatives as probable breast anticancer MCF-7 drugs》, the research content is summarized as follows. This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with di-Et malonate in base catalyst to give Et coumarin-3-carboxylate, followed by the ammonolysis of ester (Et coumarin-3-carboxylate) with ammonia in the presence of anhydrous potassium carbonate. Treatment of 2-oxo-1H-quinoline-3-carboxylic acid with acetic anhydride, cinnamaldehyde, cinnamic acid and Me 5-phenyl-2-cyano-2,4-pentadienoate under different conditions led to the formation of 1-(substituted)azacoumarin-3-carboxylic acids (1-N-(acetyl)-azacoumarin-3-carboxylic acid, 1-N-(2-formyl-1-phenyl)vinyl-azacoumarin-3-carboxylic acids, 1-N-[2-(hydroxy)carbonyl-1-(phenyl)vinyl]-azacoumarin-3-carboxylic acid (I) and 1-N-(4-cyano-5-methoxy-5-oxo-1-Phenylpenta-1,3-diene-1-y)-azacoumarin-3-carboxylic 284 acid), resp. The structures of synthesized 1-(substituted) azacoumarin-3-carboxylic acids were confirmed based on spectroscopic methods (IR and NMR), along with elemental analyses. Interestingly compound I demonstrated probable impacts as an anti-cancer drug against the MCF-7 cell line. The mechanism of action was assessed using a flow cytometric assay. The outcomes revealed that compound I could arrest the cell cycle at G2/M phase and pre-G1 apoptosis.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., SDS of cas: 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts