Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Reference of 105-34-0.
de Abrantes, Paloma Gomes;Costa, Israel Ferreira;Falcao, Nathalia Kellyne da Silva Marinho;de Oliveira Ferreira, Joao Marcos Gomes;Junior, Claudio Gabriel Lima;Teotonio, Ercules Epaminondas de Sousa;Vale, Juliana Alves research published 《 The Efficient Knoevenagel Condensation Promoted by Bifunctional Heterogenized Catalyst Based Chitosan-EDTA at Room Temperature》, the research content is summarized as follows. An efficient heterogeneous catalyst-based low mol. weight chitosan (LWC) modified with EDTA groups were prepared and applied as a bifunctional heterogenized catalyst in the Knoevenagel Condensation reaction, promoting fast reactions between malononitrile and aldehydes or isatins at room temperature Chitosan-EDTA (LWC-EDTA) catalysts were characterized by Fourier transform IR spectroscopy (FT-IR), thermogravimetric anal. (TGA/DTA), powder X-ray diffraction (XRD). UV-Vis absorption spectrophotometry showed that the functionalization of chitosan with EDTA for 72 h promotes the most significant modification of the matrix surface compared to the others applied, reflecting shorter reaction times. The reactions using the LWC-EDTA-72 catalyst present excellent isolated yields (78-98%) in short reaction times (0.50-120 min) for differents Knoevenagel compounds Additionaly, the catalyst was easily recovered and reused up to six times without significant losses of its catalytic activity.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Reference of 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts