Application of 115279-73-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115279-73-7 name is 1-(4-Aminophenyl)cyclopentanecarbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 250 ml four-necked flask equipped with a stirrer, thermometer, and reflux condenser.Add 150 g of diethyl malonate, 18.6 g (0.1 mol) of 1-(4-aminophenyl)cyclopentylcarbonitrile II, and de-alcoholization reaction at 105-110 C for 4 hours (first amidation reaction) Excessive distillation of diethyl malonate was carried out under reduced pressure, cooled to 60-70 C, 13.0 g (0.12 mol) of 4-aminomethylpyridine IV was added, and the dealcoholization reaction was carried out for 4 hours at 110-115 C (second time) Amidation reaction). After cooling to 30-40 C, 80 g of isopropanol was added to the residue, recrystallized, filtered and dried to give 33.1 g of N-(4-pyridine)methyl-N’-4-(1-cyanocyclopentane) Phenylmalonamide, yield 91.3%, liquid phase purity 99.9%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Aminophenyl)cyclopentanecarbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Qi Yuxin; Fan Yansen; Ju Lizhu; (9 pag.)CN109810052; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts