Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Synthetic Route of 105-34-0.
Afewerki, Samson;Ma, Guangning;Deiana, Luca;Wu, Hongli;Huang, Genping;Cordova, Armando research published 《 Off-Cycle Catalyst Cooperativity in Amine/Transition Metal Combined Catalysis: Bicyclo[3.2.0]heptanes as Key Species in Co-Catalytic Enantioselective Carbocyclizations》, the research content is summarized as follows. The existence of off-cycle catalyst cooperativity in amine/metal combined catalysis was disclosed. The exptl. and d. functional theory study of the amine/metal co-catalyzed enantioselective Michael/carbocyclization cascade reaction between allenes and α,β-unsaturated aldehydes revealed that the dual catalysts can perform off-cycle cooperativity that gives access to stable bicyclo[3.2.0]heptane species that limits the carbocycle product formation. Insight into this mode of co-catalyst cooperativity sheds new light on the chiral amine/metal co-catalyzed reactions of to date and gives deeper understanding for improved future design of this type of enantioselective reactions.
Synthetic Route of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts