Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. SDS of cas: 105-34-0.
Adriaens, E.;Verstraelen, S.;Desprez, B.;Alepee, N.;Abo, T.;Bagley, D.;Hibatallah, J.;Mewes, K. R.;Pfannenbecker, U.;Van Rompay, A. R. research published 《 Overall performance of Bovine Corneal Opacity and Permeability (BCOP) Laser Light-Based Opacitometer (LLBO) test method with regard to solid and liquid chemicals testing》, the research content is summarized as follows. A prospective study of the Bovine Corneal Opacity and Permeability (BCOP) Laser Light-Based Opacitometer (LLBO) test method was conducted to evaluate its usefulness to identify chems. as inducing serious eye damage (Cat. 1) or chems. not requiring classification for eye irritation (No Cat.) applying United Nations Globally Harmonized System of Classification and Labeling of Chems. (UN GHS). The aim was to demonstrate the reproducibility of the BCOP LLBO protocol for liquids and solids and define its predictive capacity. Briefly, 145 chems. were simultaneously tested with BCOP LLBO and OP-KIT (OECD TG 437), one to two times in one laboratory When used to identify Cat. 1, the BCOP LLBO has a false neg. rate (FNR) of 24.1% (N = 56) compared to 34.8% (N = 56) for the BCOP OP-KIT, with a comparable false pos. rate (FPR, N = 89) of 18.5% and 20.8%, resp. When used to identify chems. not requiring classification (No Cat.) the BCOP LLBO and BCOP OP-KIT had a FNR (N = 104) of 6.2% and 7.2% and a FPR (N = 41) of 45.1% and 42.7%, resp. The OP-KIT and LLBO devices are interchangeable at no cost to data quality and reliability. The OP-KIT and LLBO devices are interchangeable at no cost to data quality and reliability. The performance of the LLBO is at least as good as the OP-KIT, both methods can be used to identify UN GHS Cat. 1 and UN GHS No Cat. chems.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., SDS of cas: 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts