42872-74-2, name is 3-Bromo-4-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 3-Bromo-4-methylbenzonitrile
[0097] The solution of 3-bromo-4-methylbenzonitrile (3) (2.0 g, 10 mmol), in DMF (12 mL) with Bis(pinacolato)diboron (3.4 g, 13 mmol), and Pd(OAc)2 (0.5 g, 2 mmol), and KOAc (3 g, 30 mmol) was microwaved for 3 h at 80C. The mixture was then diluted with H2O (25 mL) and extracted with EtOAc (2 x 30 mL). [0098] The organic phase was collected and dried over Na2SO4 Column chromatography (in Hexane/Ethyl acetate 9:1) afforded 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (B) as an oil, which solidified during the drying in vacuo (yield: 96%)
The synthetic route of 42872-74-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHEN, Shoujun; ZHANG, Junyi; JIANG, Jun; KOWALCZYK-PRZEWLOKA, Teresa; XIA, Zhiqiang; ZHANG, Shijie; WO2013/63385; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts