21667-62-9, Adding some certain compound to certain chemical reactions, such as: 21667-62-9, name is 3-(3-Chlorophenyl)-3-oxopropanenitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21667-62-9.
General procedure: A mixture of 4,4-dimethylpentan-2-one (2.8mL, 20mmol) and the appropriate aroylacetonitrile (20mmol), acetic acid (2.6mL, 43.3mmol), beta-alanine (180mg, 2mmol) and benzene (70mL) was heated to reflux in a Dean-Stark system. After 10h, a second addition of acetic acid (2.6mL) and beta-alanine (180mg, 2mmol) was made. After 24h, the reaction mixture was cooled to room temperature, diluted with ethyl acetate (50mL), washed with water (30mL), brine (30mL), dried (Na2SO4), and finally concentrated in vacuo. The crude residue, constituting a mixture of E- and Z-isomers, was purified by column chromatography on silica gel to furnish the derivatives 4a-g.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 21667-62-9.
Reference:
Article; Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cruz-Lopez, Olga; Cara, Carlota Lopez; Saponaro, Giulia; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Baraldi, Stefania; Moorman, Allan R.; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 148 – 166;,
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