Quality Control of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Occupational allergic contact dermatitis from 5-chloro-1-methyl-4-nitroimidazole. Author is Jolanki, Riitta; Alanko, Kristiina; Pfaffli, Pirkko; Estlander, Tuula; Kanerva, Lasse.
A 46-yr old man, working on azathioprine synthesis, developed a rash on the face, especially the eyelids, neck, and hands, after minimal exposure to the drug intermediate, AZA III, in powder form, when he weighed the chem. in small amounts without using protective gloves. This contact allergy to 5-chloro-1-methyl-4-nitroimidazole, an intermediate product of azathioprine, had not been previously reported. This compound was shown to be present in the end products, azathioprine and azathioprine tablets, in amounts sufficient to induce allergic patch test reactions in a sensitized patient. Cross-reactivity was found between 5-chloro-1-methyl-4-nitroimidazole and 3 of 6 imidazole derivatives used as antifungal drugs tested.
Different reactions of this compound(5-Chloro-1-methyl-4-nitroimidazole)Quality Control of 5-Chloro-1-methyl-4-nitroimidazole require different conditions, so the reaction conditions are very important.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts