Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, MedChemComm called Design, synthesis, and structure-activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists, Author is Adam, Julia M.; Cairns, Jim; Caulfield, Wilson; Cowley, Phillip; Cumming, Iain; Easson, Morag; Edwards, Darren; Ferguson, Morag; Goodwin, Richard; Jeremiah, Fiona; Kiyoi, Takao; Mistry, Ashvin; Moir, Elizabeth; Morphy, Richard; Tierney, Jason; York, Mark; Baker, James; Cottney, Jean E.; Houghton, Andrea K.; Westwood, Paul J.; Walker, Glenn, which mentions a compound: 128717-77-1, SMILESS is O=C(C1=CNC2=C1C=CC=C2OC)O, Molecular C10H9NO3, Synthetic Route of C10H9NO3.
A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clin. evaluation as a potential i.v. analgesic agent.
Although many compounds look similar to this compound(128717-77-1)Synthetic Route of C10H9NO3, numerous studies have shown that this compound(SMILES:O=C(C1=CNC2=C1C=CC=C2OC)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts