Related Products of 117918-23-7. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Effect of dipeptidomimetics on malaria parasite proliferation inhibition targeting plasmepsin. Author is Hidaka, Koushi; Kimura, Tooru; Uemura, Tsuyoshi; Ruben, Adam J.; Freire, Ernesto; Kiso, Yoshiaki.
To improve the antimalarial activity of peptidomimetic plasmepsin (Plm) inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified a methylamino compound, i.e., KNI-10283, with 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining Plm inhibitory activity and low cytotoxicity.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts