The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.Recommanded Product: 2,9-Dimethyl-1,10-phenanthroline hemihydrate. The article 《Novel nitroimidazoles with trypanocidal and cell growth inhibition activities》 in relation to this compound, is published in Cytobios. Let’s take a look at the latest research on this compound (cas:4897-25-0).
Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, affects 18 million people in Latin America and is an important cause of heart disease. Although transmission has been reduced, an effective therapy for the infected population is lacking. New nitroimidazoles were designed and synthesized aimed at the development of a trypanocidal drug. The coupling of nitroimidazoles with heterocyclic N-trifluoromethyltriazolyl and pyrazolyl groups, 5-[N-(3-(5-trifluoromethyl)-1H-1,2,4-triazolyl)]amino-1-methyl-4-nitroimidazole (compound 4) and 5-N-(1-pyrazolyl)-1-methyl-4-nitroimidazole (compound 5). The in vitro trypanocidal effects of compounds 4 and 5 were evaluated. The results demonstrated that compound 5 was the most active compound, killing about 100% and 64% of the parasites in 0.3 mg/mL and 0.003 mg/mL concentrations, resp. Interestingly, compound 4 also inhibited myeloma cell growth in a dose-dependent manner.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Chloro-1-methyl-4-nitroimidazole)Formula: C4H4ClN3O2, illustrating the importance and wide applicability of this compound(4897-25-0).
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts