Electric Literature of C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. Author is Saadeh, Haythem A.; Mosleh, Ibrahim M.; El-Abadelah, Mustafa M..
A number of 5-aryl-1-methyl-4-nitroimidazoles 5a-f have been synthesized in good yields by the Suzuki coupling reaction between 5-chloro-1-methyl-4-nitroimidazole and arylboronic acids, in the presence of dichlorobis(triphenylphosphine)palladium(II), K2CO3, and tetrabutylammonium bromide in water at 70-80 °C. On the basis of in vitro screening data, 5-(3-chlorophenyl)-1-methyl-4-nitro-1H-imidazole (I) exhibited potent lethal activity against Entamoeba histolytica and Giardia intestinalis with IC50 = 1.47 μM/mL, a value lower by a factor of two than that of the standard drug, metronidazole. The boosted activity of I was not accompanied by any increased cytotoxicity. The rest of the series also exhibited potent antiparasitic activity with IC50 values in the 1.72-4.43 μM/mL range. The cytotoxicity of 4-MeO and 4-Cl derivatives was increased compared to the precursor compound, metronidazole, although they remain non-cytotoxic at concentrations much higher than the antiparasitic concentration of the two derivatives
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts