Related Products of 4897-25-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitroimidazole. Author is Watts, M. E.; Hodgkiss, R. J.; Sehmi, D. S.; Woodcock, M..
5-Chloro-1-methyl-4-nitroimidazole (I) [4897-25-0] (0.1 mmol/dm3) gave a sensitizer enhancement ratio (SER) of 1.7 when irradiated under steady-state conditions with 250 kVp x-rays (dose rate 3.93 Gy/min) using V79 379A cells in Eagles MEM with or without 15% fetal calf serum. Irradiation with 25 MeV electrons in a rapid-mix apparatus with 0.15 mmol I/dm3 flowing through both tubes gave an SER of 1.5 in hypoxia. No change in SER was observed when air or O-saturated I solution (0.15 mmol/dm3) in Eagle’s MEM was added to cells irradiated in hypoxic I solution (0.15 mmol/dm3) 17 ms after irradiation was complete. The fact that adding O to prevent dehalogenation of the radical did not reduce the SER suggested that elimination of the ortho-substituted ‘leaving group’ is not responsible for the observed, anomalously high efficiency.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts