Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4556-23-4, is researched, SMILESS is SC1=CC=NC=C1, Molecular C5H5NSJournal, Article, Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy called Effect of the functionalization agent on the surface-enhanced Raman scattering (SERS) spectrum: Case study of pyridine derivatives, Author is Dumont, Elodie; De Bleye, Charlotte; Haouchine, Merzouk; Coic, Laureen; Sacre, Pierre-Yves; Hubert, Philippe; Ziemons, Eric, the main research direction is functionalization agent surface enhanced raman scattering pyridine derivative; Aggregation; Functionalization agents; Pyridine derivatives; Stability; Surface-enhanced Raman scattering (SERS).HPLC of Formula: 4556-23-4.
Nowadays, the use of functionalized surface-enhanced Raman scattering (SERS) substrates has become common. These surface modifying agents notably act as Raman reporters, as sensors of biol. processes (pH, redox probes) or to increase the sensitivity and/or the specificity of SERS detections. However, the effects of the functionalization agents are deeply examined in very few studies, even though they can affect the aggregation behavior of the SERS substrate. Moreover, depending on their concentration and on the pH, their spectral signature can be modified and they can even degrade if stored inappropriately. In this context, this paper aims at emphasizing the importance of the different aspects previously listed in the selection of a functionalization agent. Pyridine derivatives were picked out to highlight these parameters, as some of these compounds are commonly used to be grafted onto SERS substrates. Two widespread syntheses of nanoparticles were selected as SERS substrates: citrate-reduced gold and silver nanoparticles. The surface of the nanoparticles was functionalized with several pyridine derivatives at different concentrations and in several solvents. It was observed that the mols. under study had a concentration-dependent effect on nanoparticle aggregation. A stability study was furthermore conducted in order to determine the best preservation conditions of the grafting solutions In conclusion, this paper shines a light on the relevance of the investigation of the too-often neglected behavior of the surface modifying agents. Before their application in SERS analyses, parameters such as the label concentration should therefore be included in an exptl. design to optimize the sample preparation
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts