Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Non-protein thiols and cellular response to drugs and radiation.Name: 5-Chloro-1-methyl-4-nitroimidazole.
The effects of misonidazole and other radiosensitizers on cellular nonprotein thiol (NPSH) levels were studied in Ehrlich ascites tumor and V-79 cells. The relative NPSH remaining after incubation under aerobic conditions with 0.1 mM drug for 0.5 h at 37° ranged from 0.01 for chlorodinitrobenzene to 0.88 for BSH (a sulfonylnitroimidazole) in tumor cells and from 0.01 for chlorodinitrobenzene to 0.82 for SR 2555 in V-79 cells. Possible mechanisms for NPSH removal are also discussed. Studies on compound reactivity with GSH in buffered solution showed 38087 (nitroimidazole derivative) to be most reactive, followed by MJL-1-191-VII, SK 21981, (both sulfamylnitroimidazoles), and CMNI (chloromethylnitroimidazole). The radiosensitizing effectiveness of dimethyl fumarate (DMF) used alone or in combination with misonidazole was also studied in hypoxic V-79 cells. DMF had little effect on the radiation response of hypoxic cells but the combination of DMF and misonidazole was more effective than either drug alone.
Here is just a brief introduction to this compound(4897-25-0)Name: 5-Chloro-1-methyl-4-nitroimidazole, more information about the compound(5-Chloro-1-methyl-4-nitroimidazole) is in the article, you can click the link below.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts