Synthetic Route of C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about The synthesis of aryl 4-nitro-5-imidazolyl sulfone radiation sensitizers sterically protected against glutathione reaction. Author is Egolf, Roger A.; Heindel, Ned D..
Title sulfones I (R1 = R2 = Me, R3 = OCH2CO2H; R1 = Cl, R2 = Me, Cl, R3 = H; R1 = R3 = Cl, R2 = CO2H) were prepared by treating chloroimidazole II with thiophenols III in the presence of NH3 in EtOH and oxidizing the resulting sulfides with H2O2 in HOAc. Title neopentyl derivatives IV (R1 = R2 = Me, R3 = OCH2CO2H; R1 = Cl, R2 = Me, Cl, R3 = H; R1 = CO2Me, R2 = R3 = H) were prepared similarly. I and V were tested as radiation sensitizers of hypoxic carcinoma cells. These sterically crowded imidazoles show decreased displacement reactivity with glutathione at C-5, a major metabolic reaction known to deplete effective plasma drug levels in traditional aryl imidazolyl sulfone radiation sensitizers.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts