So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hamlyn, Richard J.; Jones, Richard H.; Ramsden, Christopher A. researched the compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ).SDS of cas: 4897-25-0.They published the article 《Carbon-carbon bond formation via thermal intermolecular hydrogen atom transfer: two serendipitous heterocyclic examples》 about this compound( cas:4897-25-0 ) in Perkin 1. Keywords: chloro nitro thiophene reaction benzyl dihydro imidazole; imidazolyl thienyl methanol preparation crystal mol structure. We’ll tell you more about this compound (cas:4897-25-0).
Formation of an anomalous 3-nitrothiophene product, encountered during the preparation of potential bioreductive anti-cancer agents, is rationalized in terms of a hydrogen atom transfer mechanism which also accounts for the unexpected formation of previously described 5,5′-biimidazoles. Thus, reaction of 2-chloro-3-nitrothiophene with 2-benzyl-4,5-dihydro-1H-imidazole in propionitrile containing mol. sieves gave 62% imidazolylthienylmethanol I, which was x-ray crystallog. characterized.
This literature about this compound(4897-25-0)SDS of cas: 4897-25-0has given us a lot of inspiration, and I hope that the research on this compound(5-Chloro-1-methyl-4-nitroimidazole) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts