Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 484-47-9, is researched, SMILESS is C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1, Molecular C21H16N2Journal, ChemistrySelect called Ultrasound-Promoted Mild, and Efficient Protocol for Three-Component Synthesis of 2,4,5-Trisubstituted Imidazoles Using Urea and PPh3 as the Sources of Nitrogen and Organocatalyst, Author is Behrouz, Somayeh; Navid Soltani Rad, Mohammad; Abdollahzadeh, Mahla; Amin Piltan, Mohammad, the main research direction is aldehyde benzil urea triphenyl phosphine ethylene glycol three component; diphenyl alkylimidazole preparation green chem.Application In Synthesis of 2,4,5-Triphenylimidazole.
Catalytic activity of PPh3 as a cheap and efficient organocatalyst was reported for synthesis of 2,4,5-trisubstituted imidazoles. Ultrasonic assisted one-pot, three-component reaction of benzil, aldehydes, urea and PPh3 in ethylene glycol as a green solvent at room temperature has been achieved to afford the structurally diverse 2,4,5-trisubstituted imidazoles in 80-95%. The effect of different parameters on the reaction progress was also discussed. Utilizing ultrasonic irradiation dramatically improved the reaction in terms of yields and reaction times compared to conventional heating technique. The current protocol offered many advantages such as mild reaction conditions, short reaction time, the use of non-metallic, harmless, and cheap catalyst, ease of separation and purification, simple work-up procedure, and the reactivity to all types of aldehydes particularly the aliphatic aldehydes.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts