Recommanded Product: 95-11-4. Recently I am researching about PALLADIUM-CATALYZED ALKYLATION; LATE-STAGE FUNCTIONALIZATION; AROMATIC FUNCTIONALIZATION; SELECTIVE ALKYLATION; COUPLING REACTIONS; ARYL IODIDES; REAGENTS; BONDS; ACTIVATION; NORBORNENE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21602161, 21871213, 21801193]; Wuhan University; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2016M602339, 2018M642894]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gao, QW; Shang, Y; Song, FZ; Ye, JX; Liu, ZS; Li, LS; Cheng, HG; Zhou, QH. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile
We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and methylating reagent, respectively. Six types of ipso terminations can modularly couple with this ortho C-H methylation to constitute a versatile methylation toolbox for preparing diversified methylated arenes. This toolbox features inexpensive methyl sources, excellent functional-group tolerance, simple reaction procedures, and scalability. Importantly, it can be uneventfully extended to isotope-labeled methylation by switching to the corresponding reagents CD3OTs or (CH3OTs)-C-13. Moreover, this toolbox can be applied to late-stage modification of biorelevant substrates with complete stereoretention. We believe these salient and practical features of our dual-tasked methylation toolbox will be welcomed by academic and industrial researchers.
Recommanded Product: 95-11-4. Welcome to talk about 95-11-4, If you have any questions, you can contact Gao, QW; Shang, Y; Song, FZ; Ye, JX; Liu, ZS; Li, LS; Cheng, HG; Zhou, QH or send Email.
Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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