Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26391-06-0, name is 2-Cyano-N,N-diethylacetamide, A new synthetic method of this compound is introduced below., Safety of 2-Cyano-N,N-diethylacetamide
A mixture of 3-formyl-5-(2-hydroxyethyl)benzonitrile (315 mg, 1.8 mmol), 2-cyano- (1007) N,N-diethylacetamide (252 mg, 1.8 mmol) and ammonium acetate (693 mg, 9mmol) in methanol (10 mL) was stirred at reflux temperature for 4 h. Cooled and concentrated. The residue was diluted with EtOAc (50 mL), and washed with water (50 mL) and brine (50 mL). The organic layers were dried over Na2S04 and concentrated. The crude residue was purified by silica gel chromatography to afford the title compound as a yellow gum (210 mg, 49 %).
The synthetic route of 26391-06-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (171 pag.)WO2019/99576; (2019); A1;,
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