Discovery of 403-54-3

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H4FN

General procedure: CAUTION: Zn(ClO4)2.6H2O can cause skin and serious eye irritation and appropriate care should be taken in its use. In general, perchlorates are explosive compounds and appropriate caution should be taken including the avoidance of evaporation to dryness of perchlorate-containing residues. A mixture of the nitrile (1 mmol), halohydrocarbon (1.2 mmol) and Zn(ClO4)2¡¤6H2O (5 mol%) was placed in a round-bottom flask. Then the reaction mixture was heated at 80 C for the given time. After completion of the reaction (monitored by TLC), water (5mL) was added to the reaction mixture which was then extracted with ethyl acetate (3 ¡Á 5 mL). The organic layers were collected, combined, washed with water (3 ¡Á 10 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The pure product was obtained by passing the organic extract through a silica gel (200-300 mesh) column using petroleum ether (60-90 C)/ethyl acetate (10:1-5:1) as eluent and identified by 1H NMR and 13C NMR. The 1H NMR and 13C NMR spectra of the products are shown in the Electronic Supplementary Information.

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Feng, Chengliang; Yin, Guibo; Yan, Bin; Chen, Junqing; Ji, Min; Journal of Chemical Research; vol. 42; 7; (2018); p. 383 – 386;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts