Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, A new synthetic method of this compound is introduced below., Product Details of 621-50-1
To a solution of 3 (400.0 mg, 2.47 mmol) in anhydrous THF (5 mL) was slowly added a suspension of 60% sodium hydride in mineral oil (641.4 mg, 16.03 mmol) in anhydrous THF (4.2 mL) under argon at 0 C. Methyl iodide (1.23 mL, 19.74 mmol) was added to the mixture. The temperature was allowed to rise to room temperature and stirred for 16 h. After being quenched by the addition of water, the aqueous layer was extracted with EtOAc (2 ¡Á 15 mL). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered. The residue was purified by column chromatography on silica gel (EtOAc/hexane, 5:95 to 10:90) to afford 4 (141.3 mg, 30%) as a brown solid; 1H NMR (CDCl3, 400 MHz) 8.31 (1 H, t, J = 2.3 Hz), 8.21-8.19 (1 H, m), 7.90-7.87 (1 H, m), 7.61 (1 H, t, J = 7.8 Hz), 1.79 (6 H, s); 13C NMR (CDCl3, 100 MHz) 148.5, 143.5, 131.6, 130.1, 123.3, 123.0, 120.1, 37.1, 28.9.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Suebsuwong, Chalada; Pinkas, Daniel M.; Ray, Soumya S.; Bufton, Joshua C.; Dai, Bing; Bullock, Alex N.; Degterev, Alexei; Cuny, Gregory D.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 4; (2018); p. 577 – 583;,
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