Adding a certain compound to certain chemical reactions, such as: 36282-26-5, name is 2-Bromo-4-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36282-26-5, COA of Formula: C7H3BrFN
Sodium Hydride (60% oil suspension, 20 mmol, 800 mg) is triturated with hexane and suspended in N,N-dimethylformamide (10 mL). 3-Acetylindole (10 mmol, 1.59 g) is added to the ice-cooled suspension. After 5 minutes, 2-bromo, 4-fluorobenzonitrile (14 mmol, 2.8 g) is added. The reaction is stirred at 50 degrees Celsius for 30 minutes. The reaction mixture is allowed to cool and is extracted into ethyl acetate (200 mL) and is washed with water (50 mL). The organic phase is dried over magnesium sulfate. Filtration, followed by concentration, and silica gel chromatography affords the desired 4-(3-Acetyl-indol-1-yl)-2-bromo-benzonitrile as a tan solid (0.92 g, 36%)
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Reference:
Patent; Serenex, Inc.; US2007/185184; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts