10406-25-4,Some common heterocyclic compound, 10406-25-4, name is 4-(Aminomethyl)benzonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 87 Preparation of 4-(aminomethyl)phenyl-N-hydroxyamidine (4-4) Hydroxylamine hydrochloride (7 g) was added to a solution of compound 4-3 (7 g) and NMM (4 ml) in methanol (100 ml). The mixture was stirred at ambient temperature for 3 days. The compound was purified by RP HPLC to give the title compound (7 g, 89%). MS (electrospray): 166 (M+1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Aminomethyl)benzonitrile, its application will become more common.
Reference:
Patent; Corvas International, Inc.; US2002/37857; (2002); A1;; ; Patent; Corvas International, Inc.; US6586405; (2003); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts