Adding a certain compound to certain chemical reactions, such as: 15666-97-4, name is Octyl 2-cyanoacetate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15666-97-4, Recommanded Product: Octyl 2-cyanoacetate
General procedure: Aldehyde 5a-d (1.0equiv.), cyanoalkyl acetate (3.0equiv.) and a few drops of triethylamine were dissolved in chloroform (30mL) under a nitrogen atmosphere and heated to reflux overnight. After the completion of the reaction, water was added and the product was extracted with dichloromethane, washed with brine and dried over anhydrous MgSO4. The crude product was purified by column chromatography with dichloromethane/Hexanes as eluent. It was then further purified by trituration with acetone to yield the desired compounds 1-4.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Octyl 2-cyanoacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Priyanka, Pragya; Vegiraju, Sureshraju; Lin, Jhe-Yi; Ni, Jen-Shyang; Huang, Hsun-Ying; Dwi Agustin, Rachmawati; Yau, Shueh Lin; Lin, Tzu-Chau; Chen, Ming-Chou; Dyes and Pigments; vol. 133; (2016); p. 65 – 72;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts