Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16588-02-6, name is 2-Chloro-5-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-5-nitrobenzonitrile
2-chloro-5-nitro-benzonitrile (1.83 g, 10.0 mmol) was added to a 100 mL round bottom flask and dissolved in acetonitrile (20 mL).K2CO3 (2.76 g, 20.0 mmol) and di-n-hexylamine (1.85 g, 9.98 mmol) were added with stirring, and the reaction system was heated to 80[deg.] C. for 40 h.After the reaction was completed, the mixture was cooled to room temperature, poured into dichloromethane (100 mL), washed with water (100 mL × 3) and saturated brine (100 mL), and dried over anhydrous sodium sulfate.The solvent was evaporated under reduced pressure and the crude product was purified by column chromatography (petroleum ether/ethyl acetate (V/V) = 125/2) to give a yellow oil (2.89 g, 87%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, YINGJUN; ZHANG, JIANCUN; WANG, XIAOJUN; LIN, RUNFENG; CAO, SHENGTIAN; WANG, ZHAOHE; LI, JING; (226 pag.)TWI607995; (2017); B;,
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