Adding a certain compound to certain chemical reactions, such as: 115279-73-7, name is 1-(4-Aminophenyl)cyclopentanecarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115279-73-7, Product Details of 115279-73-7
A mixture of 2-chloronicotinoyl chloride (50 mg) and 1-(4-aminophenyl)-cyclopentanecarbonitrile (1 eq) and K2CO3 (80 mg) in dichloromethane (20 ml) was stirred at RT for 30 min. The reaction was filtered and the filtrate was evaporated. The residue was mixed with 6-aminoindazole (150 mg) neat and heated at 210 C. for 2 hour. The reaction was cooled and purified by column chromatography to give the title compound. Mass: (M+1), 423.
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Reference:
Patent; Chen, Guoqing P.; US2004/259916; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts